Experimental polyarthritis in rats injected with a tumour exudate.

It has previously been observed that Murphy rat lymphosarcoma (MRLS) exudate collected from a tumour-pouch could cause typical proliferative arthritis in one or several joints (Jasmin and Richer, 1955). Such articular changes developed in a few days and were aggravated by adrenalectomy (Jasmin and Selye, 1955). It is the purpose of this communication to describe these pathological changes with reference to the regulatory action of the adrenocortical hormones. In addition, studies are reported on the inhibitory effect of oxytetracycline and sodium aurothiomalate and the isolation of a micro-organism as the causative agent.